Table 3 Candidate genes located in the vicinity of the SNPs presenting significant association with lipids, cafestol, kahweol contents, and with cafestol/kahweol ratio detected by at least two GWAS methods.
Trait | SNP | Candidate Gene | Distance (Kbp) | Functional Annotation |
|---|---|---|---|---|
Lipid | S8_25559761 | Cc08_g10680 | 48.8 | Fatty acid desaturase (FADS2) |
Cafestol | S6_7853861 | Cc06_g09670 | 13.51 | Flavin-containing monooxygenase (FCM) |
Cafestol | S11_29778697 | Cc11_g12750 | 1.42 | Cytochrome P450 704 (CYP704) |
Kahweol | S2_45775221 | Cc02_g33380 | 22.74 | Long chain acyl-CoA synthetase (LCAS) |
Ratio | S2_15335417 | Cc02_g16540 | 47.66 | Triosephosphate isomerase (TPIP1) |
Ratio | S2_48526210 | Cc02_g34890 | 95.91 | Dihydrolipoyl dehydrogenase (lpdA) |
Ratio | S6_12529278 | Cc06_g14660 | 36.99 | Momilactone A synthase (MAS) |
Ratio | S7_5138106 | Cc07_g06960 | 6.06 | Acyl-CoA N-acyltransferases (NAT) |
Ratio | S11_17488418 | Cc11_g04400 | INSIDE | TATA-binding protein-associated factor 172 (BTAF1) |
