Figure 4
Transmission blocking efficacy of serum derived from immunization with PbPfs25DR3 against field isolates of P. falciparum. To assess the ability of serum generated from regimes 3 (PbPfs25DR3/Alhydrogel 2 boosts), 4 (PbPfs25DR3/Matrix M 2 boosts) and 6 (ChAd63-Pfs25-prime/PbPfs25DR3 Matrix M-boost) to block transmission of malarial field isolates, P. falciparum gametocytes were collected from naturally infected volunteers recruited in malaria endemic localities, and DMFA subsequently performed. A range of naturally occurring gametocyte densities were assessed (A,B,C) were examined at dilutions of 1:5, 1:10 and 1:100, and control (pre-immune) serum at 1:5. Individual data points represent the number of oocysts found in individual mosquitoes 12 days post feed. Horizontal bars indicate mean intensity of infection, whilst error bars indicate S.E.M. within individual samples. For each regime, the mean reductions in intensity and prevalence at each dilution are reported in Table 2.
