Table 2 Overall transmission-blocking efficacy of serum derived from immunization with PbPfs25DR3 against field isolates of P. falciparum.

From: Immunization with Transgenic Rodent Malaria Parasites Expressing Pfs25 Induces Potent Transmission-Blocking Activity

 

PbPfs25DR3 Alhydrogel – 2 boost

PbPfs25DR3 Matrix M – 2 boost

ChAd63-Pfs25/PbPfs25DR3 Matrix M

1 in 5

1 in 10

1 in 100

1 in 5

1 in 10

1 in 100

1 in 5

1 in 10

1 in 100

Expt. A:

Inhibition in intensity (%)

77.3%***

47.8%**

90.3%***

89.1%***

87.7%***

87.3%***

98.3%***

94.5%***

54.8%**

Inhibition in prevalence (%)

9.5%

0%

38.1%***

19.1%

26.2%

42.0%*

59.5%***

40.5%**

4.7%

Expt. B:

Inhibition in intensity (%)

32.5%**

45.6%***

27.0%*

96.8%***

87.3%***

64.7%***

97.3%***

96.1%***

46.6%***

Inhibition in prevalence (%)

0%

2.0%

−1.9%

22.0% *

13.7%

4.7%

46.0%***

26.1%**

5.9%

Expt. C:

Inhibition in intensity (%)

89.0%***

59.4%**

71.7%*

83.1%***

68.5%*

62.3%*

91.5%***

90.8%***

29.7%

Inhibition in prevalence (%)

89.1%***

50%**

52.1%*

70.8%**

41.9%

47.6%*

87.5%***

83.3%***

7.7%

Overall inhibition:

Inhibition in intensity (%)

62.5%**

46.9%*

65.2%***

90.7%***

85.6%***

69.1%***

97.7%***

94.7%***

46.6%***

Inhibition in prevalence (%)

22.7%*

9.3%

32.0%***

35.6%***

28.9%**

32.7%***

71.2%***

51.0%***

5.48%

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