Figure 8
Effect of HF/HF/Stz regimen on the development of diabetic peripheral neuropathy. The peripheral nerve integrity is affected in rats submitted to the HF/HF/Stz regimen, as observed by the demyelination of medium/large fibers in sciatic nerves. White arrows correspond to normal fibers whereas black arrows indicate impaired fibers (A; upper panel, scale bar 4 µm). Impaired mitochondria are also detected by electron mic lower panel,roscopy. White and black arrows represent normal and atypical mitochondria, respectively (A; scale bar 4 µm). Quantitative analysis further confirms the loss of myelinated fibers and the presence of abnormal mitochondria (B). Data are expressed as mean ± SEM; ***P < 0.001, compared with chow fed rats; analyzed using a two-tailed Mann-Whitney U-test.
