Figure 1

The strategy used to screen the HECMs for the hepatotoxicity evaluation of DBT. (a) The chemical profiling and the fingerprint analysis of DBT extracts; (b) evaluating the hepatotoxicities of DBT extracts; (c) discovering the principal hepatotoxicity markers by three chemometric methods; (d) the assessment of hepatotoxic equivalence between candidate HECMs and original DBT extracts. HECMs: hepatotoxic equivalent combinatorial markers; DBT: Dioscorea bulbifera tuber.