Table 1 CR1 genotypes and allele frequencies in patients with chronic CD and healthy controls.
From: Human complement receptor type 1 (CR1) protein levels and genetic variants in chronic Chagas Disease
CR1 genetic variants | Control n = 102 (%) | CD Patients n = 220 (%) | Indeter minate n = 87 (%) | Cardiac n = 77 (%) | Digestive n = 19 (%) | Cardio digestive n = 31 (%) | CD Patients vs. Controls p value; OR [95% CI] | Indeterminate vs. Controls p value; OR [95% CI] | Cardiac vs. Controls p value; OR [95% CI] | Digestive vs. Controls p value; OR [95% CI] | |
|---|---|---|---|---|---|---|---|---|---|---|---|
rs17259045A/G | AA | 82 (80) | 190 (87) | 75 (86) | 69 (90) | 16 (84) | 25 (81) | ||||
AG | 20 (20) | 27 (12) | 11 (13) | 7 (9) | 3 (16) | 5 (16) | NS | NS | NS | NS | |
GG | 0 | 3 (1) | 1 (1) | 1 (1) | 0 | 1 (3) | |||||
A* | 184 (90) | 407 (92) | 161 (92) | 145 (94) | 35 (92) | 55 (89) | NS | NS | NS | NS | |
G | 20 (10) | 33 (8) | 13 (8) | 9 (6) | 3 (8) | 7 (11) | |||||
rs41274768G/A | GG | 98 (96) | 198 (90) | 80 (92) | 70 (91) | 16 (84) | 27 (87) | ||||
GA | 4 (4) | 22 (10) | 7 (8) | 7 (9) | 3 (16) | 4 (13) | NS | NS | NS | NS | |
AA | 0 | 0 | 0 | 0 | 0 | 0 | |||||
G* | 200 (98) | 418 (95) | 167 (96) | 147 (95) | 35 (92) | 58 (93) | NS | NS | NS | NS | |
A | 4 (2) | 22 (5) | 7 (4) | 7 (5) | 3 (8) | 4 (7) | |||||
rs17047660A/G | AA | 100 (98) | 202 (92) | 81 (93) | 70 (91) | 19 (100) | 28 (90) | ||||
AG | 2 (2) | 15 (7) | 5 (6) | 6 (8) | 0 | 2 (6) | NS | NS | NS | NA | |
GG | 0 | 3 (1) | 1 (1) | 1 (1) | 0 | 1 (3) | |||||
A* | 202 (99) | 419 (95) | 167 (96) | 146 (95) | 38 (100) | 58 (94) | p = 0.02; 5.06 [1.17–21.81] | NS | NS | NA | |
G | 2 (1) | 21 (5) | 7 (4) | 8 (5) | 0 | 4 (6) | |||||
rs17047661A/G | AA | 95 (93) | 183 (83) | 76 (87) | 61 (79) | 16 (84) | 27 (87) | ||||
AG | 7 (7) | 31 (14) | 9 (10) | 13 (17) | 3 (16) | 3 (10) | p = 0.015; 3.05 [1.25–7.49]1 | NS | p = 0.023; 3.74 [1.19–11.72]1 | NS | |
GG | 0 | 6 (3) | 2 (2) | 3 (4) | 0 | 1 (3) | |||||
A* | 197 (97) | 397 (90) | 161 (93) | 135 (88) | 35 (92) | 57 (92) | p = 0.0042; 3.03 [1.34–9.9] | NS | p = 0.0017; 3.96 [1.62–9.68] | NS | |
G | 7 (2) | 43 (10) | 13 (7) | 19 (12) | 3 (8) | 5 (8) | |||||
rs4844609T/A | TT | 100 (98) | 213 (97) | 84 (97) | 75 (97) | 18 (95) | 30 (97) | ||||
TA | 2 (2) | 4 (2) | 3 (3) | 1 (1.5) | 0 | 0 | NS | NS | NS | NS | |
AA | 0 | 3 (1) | 0 | 1 (1.5) | 1 (5) | 1 (3) | |||||
T* | 202 (99) | 430 (98) | 171 (98) | 151 (98) | 36 (95) | 60 (97) | NS | NS | NS | NS | |
A | 2 (1) | 10 (2) | 3 (2) | 3 (2) | 2 (5) | 2 (3) | |||||
rs6691117A/G | AA | 62 (61) | 99 (45) | 36 (41) | 39 (51) | 7 (37) | 16 (52) | ||||
AG | 33 (32) | 99 (45) | 43 (49) | 31 (40) | 8 (42) | 12 (39) | p = 0.004; 2.22 [1.26–3.53]1 | p = 0.006; 2.34 [1.28–4.27]1 | NS | NS | |
GG | 7 (7) | 22 (10) | 8 (9) | 7 (9) | 4 (21) | 3 (10) | |||||
A* | 157 (77) | 297 (68) | 115 (66) | 109 (71) | 22 (58) | 44 (71) | p = 0.015;1.60 [1.09–2.35] | p = 0.02; 1.71 [1.09–2.69] | NS | p = 0.025; 2.42 [1.18–5.0] | |
G | 47 (23) | 143 (32) | 59 (34) | 45 (29) | 16 (42) | 18 (29) | |||||
