Table 3 Reconstructed CR1 haplotypes among CD patients and controls.
From: Human complement receptor type 1 (CR1) protein levels and genetic variants in chronic Chagas Disease
CR1 haplotypes (+4659/+4721/+4808/+4841/+4868/+4883) | Controlx n = 204 (%) | CD Patient n = 440 (%) | Indetermi nate n = 174 (%) | Cardiac n = 154 (%) | Digestive n = 38 (%) | Cardio digestive n = 62 (%) | Without ECHO alteration n = 48 (%) | With ECHO alteration n = 148 (%) | Without Heart Failure n = 102 (%) | Heart Failure n = 94 (%) | Patient vs. Control p value;OR [95% CI] | Cardiac vs. Control p value; OR [95% CI] | Without ECHO Alteration vs. Control p value; OR [95% CI] | Without Heart Failure vs. Control p value; OR [95% CI] |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CR1*AGAATA | 131 (64.2) | 253 (57.5) | 99 (56.9) | 94 (61) | 17 (44.7) | 37 (59.7) | 28 (58) | 92 (62.1) | 59 (57.8) | 61 (64.9) | NS | NS | NS | NS |
CR1*AGAATG | 39 (19) | 81 (18.5) | 39 (22.4) | 22 (14.3) | 10 (26.3) | 9 (14.5) | 5 (10.4) | 20 (13.5) | 10 (9.8) | 15 (16) | NS | NS | NS | NS |
CR1*GGAATA | 20 (9.8) | 31 (7) | 12 (6.8) | 9 (5.8) | 3 (7.9) | 6 (9.7) | 5 (10.4) | 10 (6.8) | 8 (7.8) | 7 (7.4) | NS | NS | NS | NS |
CR1*AAAATG | 4 (2) | 18 (4.1) | 7 (4) | 5 (3.2) | 3 (7.9) | 2 (3.2) | 1 (2) | 5 (3.4) | 4 (3.3) | 2 (2.1) | NS | NS | NS | NS |
CR1*AGAGTG | 3 (1.5) | 23 (5.2) | 5 (2.8) | 10 (6.5) | 3 (7.9) | 4 (6.4) | 6 (12.5) | 7 (4.7) | 13 (12.7) | 0 | p = 0.035; 3.99 [1.10–14.15] | NS | p = 0.03; 5.51 [1.17–25.8] | p = 0.005; 7.77 [1.84–32.7] |
CR1*AGGGTG | 1 (0.5) | 17 (3.9) | 6 (3.4) | 8 (5.2) | 0 | 1 (1.6) | 3 (6.2) | 6 (4) | 6 (5.9) | 3 (3.2) | NS | p = 0.028; 12.15 [1.30–113] | NS | p = 0.037; 11.14 [1.15–107] |
CR1*AGAAAA | 2 (1) | 8 (1.8) | 3 (1.7) | 3 (1.9) | 2 (5.3) | 0 | 0 | 3 (2) | 0 | 3 (3.2) | NS | NS | NA | NA |
CR1*AGAGTA | 3 (1.5) | 2 (0.5) | 1 (0.6) | 1 (0.6) | 0 | 0 | 0 | 1 (0.7) | 0 | 1 (1) | NS | NS | NS | NS |
CR1*AAAATA | 0 | 2 (0.5) | 0 | 2 (1.3) | 0 | 0 | 0 | 1 (0.7) | 1 (1) | 0 | NA | NA | NA | NA |
CR1*AAGAAG | 0 | 1 (0.2) | 0 | 0 | 0 | 1 (1.6) | 0 | 1 (0.7) | 0 | 1 (1) | NA | NA | NA | NA |
CR1*GGGAAA | 0 | 1 (0.2) | 0 | 0 | 0 | 1 (1.6) | 0 | 1 (0.7) | 0 | 1 (1) | NA | NA | NA | NA |
CR1*AAGATG | 0 | 1 (0.2) | 0 | 0 | 0 | 1 (1.6) | 0 | 1 (0.7) | 1 (1) | 0 | NA | NA | NA | NA |
CR1*AGGATG | 0 | 1 (0.2) | 1 (0.6) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | NA | NA | NA | NA |
CR1*GGAGTG | 0 | 1 (0.2) | 1 (0.6) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | NA | NA | NA | NA |
CR1*AGGATA | 1 (0.5) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | NA | NA | NA | NA |
