Table 1 Angles of the chimera J-domain. The angles are defined in Fig. 3. The top four clusters from cluster analysis are compared to the crystal structure PDB ID: 4WB7.

From: Conformational Landscape of the PRKACA-DNAJB1 Chimeric Kinase, the Driver for Fibrolamellar Hepatocellular Carcinoma

 

θ1

θ2

θ3

Crystal Structure

164°

82°

164°

Cluster 1

169°

89°

166°

Cluster 2

119°

98°

101°

Cluster 3

153°

88°

145°

Cluster 4

157°

75°

163°