Figure 6 | Scientific Reports

Figure 6

From: Gene and MicroRNA Perturbations of Cellular Response to Pemetrexed Implicate Biological Networks and Enable Imputation of Response in Lung Adenocarcinoma

Figure 6

Drug response imputation model using gene expression data evaluated in TCGA dataset for response. (A) Drug response imputation model developed using gene expression data. The model consists of the additive non-zero effect of a set of genes. (B) The model was applied to tumor expression data in TCGA to impute drug response in the TCGA samples in order to correlate the novel phenotype with survival time. The imputed sensitivity phenotype was significantly associated (p = 0.006) with survival time with resistant samples showing significantly lower survival time.

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