Figure 6

mRT stimulation (Experiment 2, phase I (A–C) and phase II (D–F). In Phase I, we found that introducing an IPG of 120 µs significantly decreased the minimal amplitude required to visibly suppress movement, compared to BP stimulation (A). All three pulses were equally successful in reducing both “Total distance” (B) and “%Movement” (C) at their individually set threshold amplitude. (D) Shows automated tracking of the total distance travelled by a representative rat in BP (red), IPG120 (blue) and OFF (white) conditions. In phase II, BP and IPG120 stimulation at fixed amplitudes did not generate significantly differential effects on motor outcome, although visual inspection of the data suggests that IPG120 stimulation is the most efficacious (E,F). Data are shown as mean ± SEM (n = 5 for each group, crossover design). *p < 0.05, ***p < 0.001. Abbreviations: BP = biphasic pulse; IPG60 = interphase gap of 60 µs; IPG120 = interphase gap of 120 µs.