Table 1 Inhibition of BIU-87 cell proliferation by lidocaine alone, MMC alone or the combination of both drugs.

From: Lidocaine enhances the effects of chemotherapeutic drugs against bladder cancer

Group

OD value

Cell inhibition rate (%)

Control

0.922 ± 0.014

—

1.25 mg/mL lidocaine

0.704 ± 0.022*

23.64

2.5 mg/mL lidocaine

0.499 ± 0.014*

45.88

5 mg/mL lidocaine

0.226 ± 0.014*

75.49

0.66 mg/mL MMC

0.102 ± 0.011*

88.94

0.66 mg/mL MMC + 1.25 mg/mL lidocaine

0.065 ± 0.006*,▲

92.95

0.66 mg/mL MMC + 2.5 mg/mL lidocaine

0.045 ± 0.008*,▲

95.12

0.66 mg/mL MMC + 5 mg/mL lidocaine

0.026 ± 0.012*,▲

97.18

  1. Note: MMC, mitomycin C; OD, optical density. *P < 0.05 versus control; ▲P < 0.05 versus MMC alone.
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