Table 3 Empirical p-values obtained by random permutations using HOMA IR as primary variable and metabolites as secondary ones.

From: Consensus Clustering of temporal profiles for the identification of metabolic markers of pre-diabetes in childhood (EarlyBird 73)

Metabolite	Female p-val	Females FDR	Males p-val	Males FDR
L-asparagine	0.00775	0.07958	0.01426	0.04089
L-leucine	0.09576	0.09789	0.03131	0.04892
L-isoleucine	0.0385	0.09031	0.04877	0.05904
L-valine	0.0878	0.09393	0.00222	0.02272
2-ketobutyric acid	0.06736	0.09031	0.03037	0.04892
3-methyl-2-oxovaleric acid	0.03144	0.09031	0.03074	0.04892
Alpha-ketoisovaleric acid	0.08719	0.09393	0.012	0.03943
Unassigned metabolite signal	0.06129	0.09031	0.04616	0.05739
3-hydroxybutyric acid	0.07808	0.09031	0.00007	0.00322
L-lactic acid (¹H signal at 1.20 ppm)	0.0562	0.09031	0.09473	0.09473
L-alanine	0.01189	0.07958	0.08229	0.08603
VLDL ¹H signal 1	0.02936	0.09031	0.03391	0.04892
VLDL ¹H signal 2	0.04105	0.09031	0.05111	0.05921
VLDL ¹H signal 3	0.04694	0.09031	0.01778	0.04089
L-arginine	0.07832	0.09031	0.01047	0.03705
L-lysine	0.04167	0.09031	0.00043	0.0069
Acetic acid	0.01209	0.07958	0.00247	0.02272
N-acetyl-glycoproteins	0.01346	0.07958	0.01697	0.04089
O-acetyl-glycoproteins	0.02252	0.09031	0.05467	0.05988
Acetoacetic acid	0.07679	0.09031	0.03403	0.04892
Glutamic acid	0.09331	0.09755	0.04088	0.05429
Glutamine	0.04983	0.09031	0.0059	0.03016
Citric acid	0.06048	0.09031	0.04198	0.05429
Polyunsaturated fatty acid signal 1	0.05083	0.09031	0.07081	0.07575
Polyunsaturated fatty acid signal 2	0.01353	0.07958	0.01411	0.04089
Trimethylamine	0.03381	0.09031	0.02378	0.04591
Dimethylglycine	0.00834	0.07958	0.02318	0.04591
Creatine	0.01691	0.08643	0.00045	0.0069
Citrulline	0.053	0.09031	0.04249	0.05429
Phospholipides	0.05923	0.09031	0.03983	0.05429
Trimethylamine.N.oxide	0.01064	0.07958	0.02443	0.04591
Taurine	0.01384	0.07958	0.05264	0.05921
L-proline	0.05202	0.09031	0.02013	0.04409
Methanol	0.07076	0.09031	0.01753	0.04089
Glycine	0.0557	0.09031	0.03255	0.04892
L-serine	0.06438	0.09031	0.00799	0.03341
Creatinine	0.08476	0.09393	0.0078	0.03341
L-lactic acid (¹H signal at 4.14 ppm)	0.1	0.1	0.09382	0.09473
L-threonine	0.03829	0.09031	0.01764	0.04089
Unsaturated fatty acid signal 1	0.03264	0.09031	0.0043	0.02826
Unsaturated fatty acid signal 2	0.05561	0.09031	0.02495	0.04591
L-histidine	0.02047	0.09031	0.0032	0.02453
L-tyrosine	0.06184	0.09031	0.05277	0.05921
Formic acid	0.07178	0.09031	0.00954	0.03657
L-phenylalanine	0.06624	0.09031	0.00527	0.03016
Glucose	0.07853	0.09031	0.03085	0.04892

Numbers shown indicate the likelihood of observing a distance between the reported metabolite average curves over n = 10000 random partitions which is as large (or larger) as the one obtained by 2-way clustering of HOMA IR profiles using our algorithm. Asterisks mark the statistically significant values (p < 0.05).

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Table 3 Empirical p-values obtained by random permutations using HOMA IR as primary variable and metabolites as secondary ones.

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