Table 6 Empirical p-values obtained by random permutations using Tanner score as primary variable and metabolites as secondary ones.

From: Consensus Clustering of temporal profiles for the identification of metabolic markers of pre-diabetes in childhood (EarlyBird 73)

	Female p-val	Females FDR	Males p-val	Males FDR
(a) - Metabolites
L-asparagine	0.0692	0.31832	0.0111	0.12683
L-leucine	0.3119	0.56828	0.747	0.85905
L-isoleucine	0.3596	0.57881	0.7187	0.85905
L-valine	0.4512	0.6486	0.6727	0.83633
2-ketobutyric acid	0.016	0.2622	0.4674	0.65153
3-methyl-2-oxovaleric acid	0.3212	0.56828	0.7453	0.85905
Alpha-ketoisovaleric acid	0.6416	0.7027	0.933	0.933
Unassigned metabolite signal	0.8203	0.8203	0.8179	0.90449
3-hydroxybutyric acid	0.6324	0.7027	0.3558	0.56437
L-lactic acid (¹H signal at 1.20 ppm)	0.3126	0.56828	0.5923	0.77845
L-alanine	0.1675	0.47354	0.4298	0.61784
VLDL ¹H signal 1	0.032	0.31832	0.0869	0.23514
VLDL ¹H signal 2	0.1514	0.47354	0.2455	0.43435
VLDL ¹H signal 3	0.2034	0.478	0.0262	0.13391
L-arginine	0.0688	0.31832	0.3459	0.56437
L-lysine	0.0595	0.31832	0.0565	0.184
Acetic acid	0.0974	0.34465	0.0671	0.19291
N-acetyl-glycoproteins	0.2387	0.478	0.8455	0.90449
O-acetyl-glycoproteins	0.1853	0.47354	0.1084	0.27702
Acetoacetic acid	0.3649	0.57881	0.9006	0.92061
Glutamic acid	0.4827	0.64926	0.0557	0.184
Glutamine	0.6745	0.72156	0.0193	0.12683
Citric acid	0.3402	0.57881	0.06	0.184
Polyunsaturated fatty acid signal 1	0.2254	0.478	0.2706	0.46102
Polyunsaturated fatty acid signal 2	0.7596	0.79413	0.8657	0.90505
Trimethylamine	0.0117	0.2622	0.0037	0.0644
Dimethylglycine	0.0844	0.33695	0.0178	0.12683
Creatine	0.0657	0.31832	0.2041	0.4082
Citrulline	0.5608	0.69721	0.3891	0.57737
Phospholipides	0.1563	0.47354	0.6454	0.82468
Trimethylamine.N.oxide	0.7924	0.81001	0.0184	0.12683
Taurine	0.2181	0.478	0.2291	0.42909
L-proline	0.4909	0.64926	0.038	0.1748
Methanol	0.494	0.64926	0.1474	0.3231
Glycine	0.4158	0.61699	0.0427	0.17856
L-serine	0.239	0.478	0.5463	0.73911
Creatinine	0.3855	0.5911	0.0236	0.13391
L-lactic acid (¹H signal at 4.14 ppm)	0.6255	0.7027	0.8442	0.90449
L-threonine	0.0447	0.31832	0.2332	0.42909
Unsaturated fatty acid signal 1	0.5764	0.69775	0.1326	0.32103
Unsaturated fatty acid signal 2	0.1786	0.47354	0.0579	0.184
L-histidine	0.0879	0.33695	0.0015	0.0644
L-tyrosine	0.5223	0.66738	0.1475	0.3231
Formic acid	0.0171	0.2622	0.0042	0.0644
L-phenylalanine	0.0421	0.31832	0.1997	0.4082
Glucose	0.6299	0.7027	0.3709	0.56871
(b) - Anthropometric variables
Bone mass	0.0019	0.00585	0.5863	0.5688
Fat mass	0.02	0.0207	0.0948	0.5688
Lean mass	0.0027	0.00585	0.8486	0.5688
Bone mass (total body less head)	0.0031	0.00585	0.604	0.5688
Fat mass (total body less head)	0.0207	0.0207	0.0948	0.5688
Lean mass (total body less head)	0.0039	0.00585	0.8845	0.8845

Numbers shown indicate the likelihood of observing a distance between the reported metabolite average curves over n = 10000 random partitions which is as large (or larger) as the one obtained by 2-way clustering of Tanner score profiles using our algorithm. Asterisks mark the statistically significant values (p < 0.05). (a) Metabolites. (b) Anthropometric variables. Anthropometric variables were analyzed separately because they were available for a range of time points different than the other variables.

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Table 6 Empirical p-values obtained by random permutations using Tanner score as primary variable and metabolites as secondary ones.

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