Figure 2
From: House dust mite induced allergic airway disease is attenuated in CD11ccreIL-4Rα−/l°x mice
Allergic airway disease in CD11ccreIL-4Rα−/lox mice in the OVA model without alum (day 24). (A) Airway resistance and elastance after methacholine challenge at day 21 in OVA-sensitized and challenged mice. (B) Eosinophils and neutrophils in the airways and lungs of challenged mice. (C) Cytokines measured by ELISA after restimulation of draining lymph node cells with OVA or (D) anti-CD3. (E) Mucus hypersecretion in the airways (100× magnification). (F) Goblet cell hyperplasia. HMI = histology mucous index. All graphs are representative of 2 experiments, with n = 5–6 per experiment. Significant differences are shown between IL-4Rα−/lox PBS and the other groups unless otherwise indicated by brackets. *P < 0.05; **P < 0.01; ***P < 0.001.
