Figure 4

Immunohistochemical analysis of citrullinated proteins in murine lymphoid organs and kidneys. Mice were injected with PBS (vehicle) or NiNPs, S-NiNWs and L-NiNWs and the organs were analysed after 24 h and 2 weeks. LN and kidney tissue sections were stained with anti-citrulline antibody. Protein citrullination in LN (a) spleen (b) and kidney tissue sections (c) sections were compared to their group controls. p-values of <0.0001 are indicated by ***. Statistical analysis between the different experimental groups is reported in Table S1.