Table 1 Previously identified genetic variants from genome-wide association studies and risk of childhood B-cell ALL in Japanese.

From: Regional evaluation of childhood acute lymphoblastic leukemia genetic susceptibility loci among Japanese

Gene/SNPa

Chr: Positionb

Alleles

Cases (MAF) n = 527

Controls (MAF) n = 3,882

OR (95% CI)c

P

ARID5B (10q21.2)

rs10994982

10:63,710,104

G/A

0.583

0.466

1.58 (1.37–1.82)

3.83 × 10−10

rs10821936

10:63,723,577

T/C

0.500

0.345

1.84 (1.60–2.13)

6.04 × 10−17

rs7089424

10:63,752,159

T/G

0.489

0.344

1.76 (1.53–2.03)

7.77 × 10−15

IKZF1 (7p12.2)

rs11978267

7:50,466,304

A/G

0.092

0.097

1.13 (0.89–1.44)

0.321

rs4132601

7:50,470,604

T/G

0.091

0.092

1.19 (0.93–1.51)

0.164

CEBPE (14q11.2)

rs4982731

14:23,585,333

T/C

0.136

0.133

1.11 (0.91–1.37)

0.306

rs2239633

14:23,589,057

G/A

0.452

0.467

0.93 (0.80–1.07)

0.282

CDKN2A, CDKN2B (9p21.3)

rs3731217

9:21,984,661

A/C

0.191

0.183

1.11 (0.93–1.33)

0.251

rs662463

9:22,030,438

G/A

0.011

0.013

0.85 (0.45–1.62)

0.625

rs17756311

9:22,053,895

G/A

0.010

0.012

0.88 (0.45–1.71)

0.695

PIP4K2A (10p12.2)

rs10828317

10:22,839,628

T/C

0.331

0.390

0.76 (0.65–0.88)

3.03 × 10−4

rs7088318

10:22,852,948

A/C

0.333

0.390

0.76 (0.65–0.88)

2.43 × 10−4

GATA3 (10p14)

rs3824662

10:8,104,208

C/A

0.339

0.307

1.15 (1.00–1.33)

0.058

LHPP (10q26.13)

rs35837782

10:126,293,309

G/A

0.414

0.393

1.06 (0.92–1.22)

0.442

ELK3 (12q23.1)

rs4762284

12:96,612,762

T/A

0.415

0.430

0.93 (0.80–1.07)

0.303

WWOX (16q23.1)

rs1121404

16:79,089,869

T/C

0.412

0.383

1.04 (0.90–1.19)

0.623

  1. Abbreviations: Chr, chromosome; CI, confidence interval; MAF, minor allele frequency; OR, odds ratio; SNP, single nucleotide polymorphism.
  2. aSNPs showing the strongest associations in previous genome-wide association studies (GWAS) within the identified region was selected. If multiple GWAS conducted in the same racial/ethnic population reported different SNPs, but tagged the same genomic region, SNPs from the first report were selected.
  3. bGenomic positions are based on the human genome assembly GRCh37 coordinates.
  4. cOdds ratios and 95% confidence intervals were calculated using logistic regression assuming a log-additive genetic model and adjusting for 10 PCA eigenvectors.
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