Figure 7 | Scientific Reports

Figure 7

From: Role of hypoxia in Diffuse Large B-cell Lymphoma: Metabolic repression and selective translation of HK2 facilitates development of DLBCL

Figure 7

HK2 is required for lymphoma growth. HK2 levels were genetically inhibited using lentiviral particles expressing NT-shRNA and sh-HK2 in HLY cell lines and growth effects were monitored. Total cell counts were performed over a period of one week. (A) Normoxia (21% oxygen). (B) Hypoxia (1% oxygen). (C) The effect of HK2 inhibition on tumorigenesis in vivo. HLY cells transduced with NT-shRNA and sh-HK2 lentiviruses were subcutaneously injected into NSG mice and tumor growth was monitored. The top panel shows representative tumor images. Tumor values were calculated from n = 8 animals per group ±SE, p < 0.05. (D) Model figure-representing effect of hypoxia on various cellular processes that effectively coordinate to respond to hypoxic stress during DLBCL development.

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