Table 2 Fifty-two candidate genes and the LOD score of each in the pedigree.

From: Mutations in bassoon in individuals with familial and sporadic progressive supranuclear palsy-like syndrome

No	Gene	Associated disease	Official name	Chromosome	Start*	End*	LOD score**
1	APP	Alzheimer’s disease	APP	21	27,252,861	27,543,446	Less than 0
2	PSEN1	Alzheimer’s disease	PSEN1	14	73,603,143	73,690,399	Less than 0
3	PSEN2	Alzheimer’s disease	PSEN2	1	227,057,885	227,083,804	Less than 0
4	MAPT	Frontotemporal lobar degeneration	MAPT	17	43,971,702	44,105,700	Less than 0
5	C9ORF72	Frontotemporal lobar degeneration	C9ORF72	9	27,546,543	27,573,864	Less than 0
6	TARDBP	Frontotemporal lobar degeneration	TARDBP	1	11,072,462	11,085,549	Less than 0
7	FUS	Frontotemporal lobar degeneration	FUS	16	31,191,431	31,206,192	Less than 0
8	VCP	Frontotemporal lobar degeneration	VCP	9	35,056,065	35,072,739	Less than 0
9	GRN	Frontotemporal lobar degeneration	GRN	17	42,422,491	42,430,474	Less than 0
10	CHMP2B	Frontotemporal lobar degeneration	CHMP2B	3	87,276,413	87,304,698	Less than 0
11	DNAJB6	Frontotemporal lobar degeneration	DNAJB6	7	157,129,692	157,210,133	Less than 0
12	PRNPIP	Other dementia	ERI3	1	44,686,742	44,821,315	Less than 0
13	CSF1R	Other dementia	CSF1R	5	149,432,854	149,492,935	Less than 0
14	SNCA	Parkinsonism	SNCA	4	90,645,250	90,759,447	Less than 0
15	PARK2	Parkinsonism	PARK2	6	161,768,590	163,148,834	1.4769
16	UCHL1	Parkinsonism	UCHL1	4	41,258,898	41,270,446	1.4769
17	LRRK2	Parkinsonism	LRRK2	12	40,618,813	40,763,087	Less than 0
18	PINK1	Parkinsonism	PINK1	1	20,959,948	20,978,004	Less than 0
19	DJ1	Parkinsonism	PARK7	1	8,021,714	8,045,342	Less than 0
20	ATP13A2	Parkinsonism	ATP13A2	1	17,312,453	17,338,467	Less than 0
21	GIGYF2	Parkinsonism	GIGYF2	2	233,562,015	233,725,287	Less than 0
22	Omi/HTRA2	Parkinsonism	HTRA2	2	74,756,532	74,760,683	Less than 0
23	PLA2G6	Parkinsonism	PLA2G6	22	38,507,502	38,577,857	Less than 0
24	FBXO7	Parkinsonism	FBXO7	22	32,870,707	32,894,818	Less than 0
25	NUCKS1	Parkinsonism	NUCKS1	1	205,681,947	205,719,372	Less than 0
26	VPS35	Parkinsonism	VPS35	16	46,693,589	46,723,144	Less than 0
27	EIF4G	Parkinsonism	EIF4G1	3	184,032,283	184,053,146	Less than 0
28	DCTN1	Parkinsonism	DCTN1	2	74,588,281	74,619,214	Less than 0
29	POLG1	Mitochondrial disease	POLG	15	89,859,536	89,878,026	Less than 0
30	POLG2	Mitochondrial disease	POLG2	17	62,473,902	62,493,184	Less than 0
31	PEO1	Mitochondrial disease	C10orf2	10	102,747,293	102,754,159	Less than 0
32	ANT1	Mitochondrial disease	SLC25A4	4	186,064,417	186,071,538	Less than 0
33	STX6	Progressive supranuclear palsy	STX6	1	180,942,164	180,992,074	Less than 0
34	EIF2AK3	Progressive supranuclear palsy	EIF2AK3	2	88,856,259	88,927,094	Less than 0
35	MOBP	Progressive supranuclear palsy	MOBP	3	39,509,064	39,570,988	Less than 0
36	GBA	Others	GBA	1	155,204,239	155,214,653	Less than 0
37	NPC1	Others	NPC1	18	21,086,148	21,166,581	Less than 0
38	CYP27A1	Others	CYP27A1	2	219,646,472	219,680,016	Less than 0
39	TNPO1	Others	TNPO1	5	72,112,418	72,210,215	Less than 0
40	UBQLN1	Others	UBQLN1	9	86,274,878	86,323,168	Less than 0
41	UBQLN2	Others	UBQLN2	X	56,590,025	56,593,443	Not analysed
42	SQSTM1	Others	SQSTM1	5	179,233,388	179,265,078	Less than 0
43	ATXN1	Others	ATXN1	6	16,299,343	16,761,721	Less than 0
44	ATXN2	Others	ATXN2	12	111,890,018	112,037,480	Less than 0
45	ATXN3	Others	ATXN3	14	92,524,896	92,572,965	1.4769
46	ATN1	Others	ATN1	12	7,033,626	7,051,484	Less than 0
47	TBP	Others	TBP	6	170,863,384	170,881,958	Less than 0
48	GFAP	Others	GFAP	17	42,982,994	42,992,920	Less than 0
49	RGPD5	Others	RGPD5	2	110,550,335	110,615,268	Less than 0
50	RAN	Others	RAN	12	131,356,617	131,362,220	Less than 0
51	DNAJC6	Others	DNAJC6	1	65,720,133	65,881,552	Less than 0
52	NOP56	Others	NOP56	20	2,633,178	2,639,039	Less than 0

*Chromosome numbers and positions are based on GRCh37.p13.
**The maximum LOD in the linkage analysis of this family was 1.4769.

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Table 2 Fifty-two candidate genes and the LOD score of each in the pedigree.

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