Figure 6
Expression of miRNA-340 in lymphocytes and whole blood cells in response to glucose and insulin miRNA expression in non-cultured and cultured lymphocytes of eight pregnant women was investigated. (A) Comparison of non-cultured (no treatment, non-colored bars) and lymphocytes cultured with 5.5 mM (blue bars) or 25.5 mM (violet bars) glucose. (B) Comparison of cells cultured in medium containing 5.5 mM glucose without and with 100 nM insulin (light blue bars), respectively, and cells cultured in medium containing 25.5 mM glucose without and with 10 nM insulin (light violet bars), respectively. miRNA expression in whole blood cells (WBCs) in relation to fasting insulin (C) and glucose (D) levels within the validation cohort (N = 30). Shown are means ± SD. Statistically significant P-values (P ≤ 0.05) are marked by bold fonts.
