Figure 2 | Scientific Reports

Figure 2

From: A hypoxia- and telomerase-responsive oncolytic adenovirus expressing secretable trimeric TRAIL triggers tumour-specific apoptosis and promotes viral dispersion in TRAIL-resistant glioblastoma

Figure 2

Cancer cell-specific killing effect of the oncolytic adenoviruses. (a) Glioblastoma cells (U87MG and U251N) and (b) normal cells (BJ and SVG-P12) were infected with Rb7Δ19, H5CmTERT-Ad, or H5CmTERT-Ad/TRAIL at the indicated  MOI and incubated under normoxic or hypoxic conditions. At 48 h after the infection, cell viability was measured by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Each cell line was tested at least three times, and data are shown as mean ± SD of triplicate experiments; *P < 0.05, **P < 0.01, ***P < 0.001.

Back to article page