Figure 5 | Scientific Reports

Figure 5

From: A hypoxia- and telomerase-responsive oncolytic adenovirus expressing secretable trimeric TRAIL triggers tumour-specific apoptosis and promotes viral dispersion in TRAIL-resistant glioblastoma

Figure 5

Assessment of the anti-tumour effect and survival rate in a subcutaneous glioblastoma xenograft model. U87MG glioblastoma xenograft tumours received three doses of PBS, H5CmTERT-Ad, or H5CmTERT-Ad/TRAIL (5 × 109 VPs) via intratumoural injection on days 1, 3, and 5 (vertical arrows). Tumour growth was monitored at 2-day intervals by measuring the width (W) and length (L) of the tumour. Tumour volume was estimated with the following formula: volume = 0.523 × L × W2. *P < 0.05, **P < 0.01. 

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