Figure 7

Proposed AKAP12 mechanism to mediate meningioma aggressiveness: Gene names are shown at the approximate positions where their encoded proteins function in the pathway. Although the general organization of the pathway is correct, some details are omitted. Colored molecules were identified experimentally. Grey molecules: affected with no significant changes in regulation. Red molecules: upregulation. Green molecules: downregulation. Purple lines: proposed mechanism in atypical tumors. Black lines: proposed mechanism anaplastic tumors. Grey lines: proposed AKAP12 mechanism in meningioma. Purple and black thick lined boxes indicate atypical and anaplastic signatures, respectively.