Figure 8 | Scientific Reports

Figure 8

From: Targeted inhibitors of P-glycoprotein increase chemotherapeutic-induced mortality of multidrug resistant tumor cells

Figure 8

Compounds 29, 34 and 45 are inhibitors of P-gp and not transport substrates. Quantitative LC-MS/MS analysis of intracellular accumulation of 29 (panel A), 34 (panel B), 45 (panel C), or daunorubicin (panel D) in DU145 TXR. Each histogram represents the average ± S.D. (n = 3, two independent experiments); **P < 0.01; NS – not significant). DNR, daunorubicin; TQR, tariquidar.

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