Figure 5
A model for draxin function in postnatal neurogenesis of the DG. In the neurogenic regions of the postnatal DG, draxin is expressed only in Tbr2 (+) late progenitors and DCX/NeuroD1 (+) neuroblasts, but not in other granule cell lines or glial cells (A). On the other hand, the draxin receptor DCC, a dependence receptor, is principally expressed in neuroblasts (A), where it induces apoptosis in a caspase-dependent manner in the absence of draxin (B). However, the DCC-induced apoptosis is prevented in the presence of draxin (B’). Thus, draxin secreted from late progenitors and neuroblasts could prevent neuroblasts from undergoing DCC-induced apoptosis during differentiation.
