Table 1 Demographic, clinical symptoms and laboratory parameters in neonates with RSV only and RSV codetected with bacteria.

From: Recurrent wheezing in neonatal pneumonia is associated with combined infection with Respiratory Syncytial Virus and Staphylococcus aureus or Klebsiella pneumoniae

 

RSV only n = 341

RSV codetected with bacteria n=265

P0 value

RSV–Escherichia coli n = 98

P1 value

RSV–Klebsiella pneumonia n = 81

P2 value

RSV–Staphylococcus aureus n = 53

P 3 ‘ value

RSV–Enterobacter cloacae n = 33

P4 value

Demographic Data

Age (day)

15 [11–20]

16 [12–21]

0.956

15 [12–19]

0.987

16 [12.5–20.5]

0.895

13 [11–18]

0.575

17 [12.5–20]

0.549

Gestational age at birth(week)

39 [38.2–39.6]

39 [38–40]

0.348

39 [38.2–39.5]

0.582

38 [37.4–38.7]

0.473

39 [38.3–39.7]

0.671

39 [38.5–39.6]

0.739

Sex (male,%)

188 (55.1)

154 (58.1)

0.463

58 (59.2)

0.476

53 (65.4)

0.092

27 (50.9)

0.569

16 (48.5)

0.464

Weight(g)

3600 [3100–4064]

3580 [3160–3920]

0.491

3503 [3200–3843]

0.374

3409 [3200–3605]

0.328

3640 [3335–3943]

0.834

3451 [3150–3798]

0.503

Birth weight(g)

3320 [3020–3590]

3300 [3000–3600]

0.996

3263 [3050–3718]

0.885

3300 [3075–3550]

0.997

3350 [3100–3680]

0.968

3250 [3000–3625]

0.516

Caesarean section (n,%)

215 (63.0)

160 (60.4)

0.502

52 (53.1)

0.074

53 (65.4)

0.689

35 (66.0)

0.674

20 (60.6)

0.781

Oxygen requirement (n,%)

144 (42.2)

158 (59.6)

<0.001

58 (59.2)

0.003

47 (58.0)

0.01

36 (67.9)

<0.001

17 (51.5)

0.304

Clinical Symptoms (n,%)

Nasal obstruction

172 (50.4)

152 (57.4)

0.09

53 (54.1)

0.525

49 (60.5)

0.103

31 (58.5)

0.275

19 (57.6)

0.434

Cough

266 (78.0)

222 (83.8)

0.075

80 (81.6)

0.439

69 (85.2)

0.151

45 (84.9)

0.252

28 (84.8)

0.46

Shortness of breath

233 (68.3)

220 (83.0)

<0.001

78 (79.6)

0.031

67 (82.7)

0.01

49 (92.5)

<0.001

26 (78.8)

0.214

Cyanosis

237 (69.5)

200 (75.5)

0.104

75 (76.5)

0.176

64 (79.0)

0.089

36 (67.9)

0.817

25 (75.8)

0.454

Moist rale

126 (37.0)

116 (43.8)

0.089

42 (42.9)

0.289

37 (45.7)

0.147

21 (39.6)

0.708

16 (48.5)

0.192

Wheezing

53 (15.5)

64 (24.2)

0.008

22 (22.4)

0.109

21 (25.9)

0.027

15 (28.3)

0.022

6 (18.2)

0.691

Chest retraction

83 (24.3)

90 (34.0)

0.009

33 (33.7)

0.065

29 (35.8)

0.036

19 (35.8)

0.075

9 (27.3)

0.709

Fever

63 (18.5)

69 (26.0)

0.025

25 (25.5)

0.125

16 (19.8)

0.791

21 (39.6)

<0.001

7 (21.2)

0.7

Diarrhoea

90 (26.4)

81 (30.6)

0.258

37 (37.8)

0.029

22 (27.2)

0.888

14 (26.4)

0.997

8 (24.2)

0.789

Laboratory tests

WBC/mm3

8.2 [7.2–9.4]

10.0 [9.6–11.1]

0.172

9.8 [8.7–11.0]

0.163

10.2 [8.9–11.2]

0.089

11.7 [10.4–13.1]

0.008

9.6 [8.5–10.9]

0.243

Eosinophils %

3 [2–4]

2 [3–5]

0.514

3.5 [2–4.5]

0.681

3.2 [2.2–4.3]

0.895

3.7 [2.5–4.7]

0.456

2.8 [2–3.8]

0.873

Platelets/mm3

305 [255–358]

379 [303–451]

0.023

368 [310–420]

0.103

393 [330–455]

0.02

420 [366–485]

0.004

372 [310–430]

0.087

Higher CRP (n,%)

32 (9.4)

57 (21.5)

<0.001

20 (20.4)

0.003

16 (19.8)

0.008

15 (28.3)

<0.001

6 (18.2)

0.11

Abnormal chest x-ray (n,%)

233 (68.3)

224 (84.5)

<0.001

80 (81.6)

0.01

71 (87.7)

<0.001

47 (88.7)

0.002

26 (78.8)

0.214

  1. WBC: white blood cell counts. Higher CRP:C-reactive protein levels were measured by scatter rate turbidity comparison, ≥8 mg/L.
  2. Abnormal x-ray: emphysema, lobar consolidation, atelectasis.
  3. Data expressed in median values with 25–75% interquartile ranges. Numbers in parenthesis represent the percentage of subjects in each group.
  4. P0 value: comparisons between RSV only and RSV with bacteria; P1 value: comparisons between RSV only and RSV–Escherichia coli;
  5. P2 value: comparisons between RSV only and RSV–Klebsiella pneumoniae; P3 value: comparisons between RSV only and RSV–Staphylococcus aureus;
  6. P4 value: comparisons between RSV only and RSV–Enterobacter cloacae. Significant P values are in bold.
  7. Mann-Whitney U test was used for continues variables and Chi-square test for analyses of categorical variables; the Bonferroni correction was applied for multiple comparisons (P < 0.01).
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