Figure 8 | Scientific Reports

Figure 8

From: Mechanical phenotyping of K562 cells by the Micropipette Aspiration Technique allows identifying mechanical changes induced by drugs

Figure 8The alternative text for this image may have been generated using AI.

Phase diagram for the possible behaviors of the cell protrusion inside the micropipette as a function of the thickness of the cortical layer, h, with respect to the critical thicknesses. The different lines represent the trend of the cell projection L p as a function of time, t. (a) Case in which the threshold thickness for protrusion retraction, h s , is lower than the thickness threshold for plasma membrane detachment from the actin cortex, h b . From the top: cell oscillations with large bleb formation, instantaneous retraction; oscillations with no bleb formation, continuous growth. (b) Case in which h s is bigger than h b . Saltatory behavior: tongue increases to a stationary situation followed by a new increase

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