Figure 2
From: A new dry eye mouse model produced by exorbital and intraorbital lacrimal gland excision
Change of tear volume in the ELG plus ILG excised mice and ELG excised mice. The graph showed the change of tear volume in the ELG plus ILG excised mice (OP+; blue line), sham operated mice (Sham OP; red line) and untreated mice (UT; green line) at 2, 4, 6, 8 and 10 weeks after surgery, as well as before surgery. For comparison, the data of ELG-only excised mice ((ELG) OP+; dotted blue line) and untreated controls ((ELG) OP-; dotted red line) were overlaid. Tear production in the ELG plus ILG excised mice (OP+; blue line) was significantly decreased compared with those receiving the sham operation (Sham OP; red line), or with untreated controls (UT; green line). The reduction of tear volume was continuously observed for 10 weeks after surgery. X-axis shows time point after surgery. Y-axis shows calculated tear volume per 1 g of animal’s body weight (BW), using a standard curve. In addition, tear production in the ELG plus ILG excised mice was significantly decreased compared with the ELG only excised mice ((ELG) OP+; dotted blue line). Each data point represents mean ± SEM. *** indicates statistical significance (P < 0.001) compared with sham OP by unpaired Student’s t-test or Welch’s t-test. ### indicates statistical significance (P < 0.001) between ELG plus ILG excised mice and ELG-only excised mice by unpaired Student’s t-test.
