Figure 4
Chronic treatment with DiOHF alleviates ER stress, oxidative stress and apoptosis in mouse aorta. Western blot and quantitative data showing ER stress markers, (A) GRP78, (B) pelF2α/elF2α; apoptosis markers, (C) CHOP, (D) cleaved caspase 3/caspase 3; (E) oxidative stress marker, NOX2 and (F) phosphorylation of eNOS at Ser 1176/eNOS in isolated aortic rings from all treatment groups. Results are mean ± SEM of 6 separate experiments. #P < 0.05 vs control, Bonferroni’s Multiple Comparison Test. ##P < 0.01 vs control, Bonferroni’s Multiple Comparison Test. ###P < 0.001 vs control, Bonferroni’s Multiple Comparison Test. *P < 0.05 vs tunica, Bonferroni’s Multiple Comparison Test. **P < 0.01 vs tunica, Bonferroni’s Multiple Comparison Test. ***P < 0.001 vs tunica, Bonferroni’s Multiple Comparison Test.
