Figure 3
From: Prevention of Retinal Degeneration in a Rat Model of Smith-Lemli-Opitz Syndrome
Electroretinographic analysis of control vs. AY9944-treated rats as a function of diet. (A) Representative dark-adapted ERG waveforms from a member of each experimental group. Flash strength is color-coded: (black: −3.6 log cd s/m2; blue: −2.4 log cd s/m2; green: −1.2 log cd s/m2; red: 0.0 log cd s/m2; red: 1.4 log cd s/m2). Summary plots are shown for (B) the amplitude of the ERG a-wave and (C) b-wave, and (D) the implicit time of the ERG b-wave. (E) Representative light-adapted cone ERG waveforms from a member of each experimental group. Flash strength is color-coded: (blue: 0.0 log cd s/m2; green: 0.9 log cd s/m2; red: 1.9 log cd s/m2). (F) Summary plots for the amplitude of the cone ERG. Data points are mean ± S.E.M. values, for n biological replicates, obtained from rats at age PN 80–82 days at time of ERG measurements: C1 group, n = 10; AY1 group, n = 9; AY2 group, n = 8; AY3 group, n = 4 (see inset, panel D, for color key). Note the overlap in data points for ERG responses from C1 and AY3 group animals. [See Results for presentation of statistical analysis of data].
