Figure 2 | Scientific Reports

Figure 2

From: Deletion of DGCR8 in VSMCs of adult mice results in loss of vascular reactivity, reduced blood pressure and neointima formation

Figure 2

DGCR8iKO mice displayed reduced blood pressure and vascular reactivity. (A,B,C) Blood pressure was measured in DGCR8iKO and control mice one month after tamoxifen injection using tail-cuff method. DGCR8iKO mice displayed significantly reduced blood pressure including systolic (A), diastolic (B) and mean (C) compared to controls (N = 5 per group, *p < 0.05). (D) DGCR8iKO mice didn’t display significant differences in heart rate compared to controls. (E and F) The vascular reactivity was measured in thoracic aorta isolated from DGCR8iKO and control mice using a wire myography. DGCR8iKO mice displayed diminished vascular response to PE (***p < 0.001) and ET-1 (***p < 0.001), respectively.

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