Table 2 Main affected pathways in 5xFAD at 6 weeks (top 200 most abundant proteins).

From: Innate immune alterations are elicited in microglial cells before plaque deposition in the Alzheimer’s disease mouse model 5xFAD

Index

Name

P-value

Adjusted p-value

Z-score

Combined score

1

JAK/STAT signaling pathway

0.0003162

0.01138

−1.44

6.43

2

PDGF signaling pathway

0.005052

0.06063

−1.46

4.09

3

p38 MAPK pathway

0.003783

0.06063

−1.40

3.94

4

General transcription regulation

0.03085

0.1915

−0.65

1.07

5

Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade

0.03292

0.1915

−0.64

1.05

6

FAS signaling pathway

0.03723

0.1915

−0.54

0.89

7

Transcription regulation by bZIP transcription factor

0.06429

0.2893

−0.69

0.86

8

General transcription by RNA polymerase I

0.009316

0.08384

−0.31

0.76

9

Ras Pathway

0.1480

0.3674

−0.54

0.54

10

Interleukin signaling pathway

0.2078

0.4280

−0.07

0.06

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