Table 3 Main affected pathways in 5xFAD at 10 weeks (top 200 most abundant proteins).
Index | Name | P-value | Adjusted p-value | Z-score | Combined score |
|---|---|---|---|---|---|
1 | Synaptic vesicle trafficking | 0.000002697 | 0.00009360 | −1.42 | 13.19 |
2 | Metabotropic glutamate receptor group II pathway | 0.00001080 | 0.0002267 | −1.47 | 12.34 |
3 | Beta3 adrenergic receptor signaling pathway | 0.000002971 | 0.00009360 | −1.12 | 10.42 |
4 | Opioid prodynorphin pathway | 0.00002609 | 0.0002348 | −0.92 | 7.72 |
5 | 5HT4 type receptor mediated signaling pathway | 0.00001576 | 0.0002348 | −0.91 | 7.63 |
6 | Opioid proopiomelanocortin | 0.00002609 | 0.0002348 | −0.85 | 7.07 |
7 | Muscarinic acetylcholine receptor 2 and 4 signaling | 0.00004056 | 0.0003194 | −0.79 | 6.38 |
8 | Muscarinic acetylcholine receptor 1 and 3 signaling | 0.00005849 | 0.0004095 | −0.76 | 5.93 |
9 | Opioid proenkephalin | 0.00002609 | 0.0002348 | −0.65 | 5.44 |
10 | Metabotropic glutamate receptor group III pathway | 0.0001974 | 0.0009568 | −0.39 | 2.68 |
