Table 1 Brain regions with significant differences between sham and SNL rats (two-sample t-test, p < 0.005, K_e > 20). The peak voxel location is represented by the distance from the bregma (mm).

Brain region	K_e	T	Z	Peak p	Location (mm)
Brain region	K_e	T	Z	Peak p	ML	AP	DV
Sham < SNL
Medial prefrontal cortex (Prelimbic and infralimbic cortices)	97	5.50	4.06	2.54E-06	0.2	2.6	−4.8
Primary somatosensory cortex (Dysgranular zone)	24	5.88	4.23	1.16E-05	−4.6	−0.2	−3.4
Primary, secondary somatosensory cortices and caudate putamen	37	4.42	3.52	0.0002	4.8	−0.4	−5.2
Retrosplenial cortex	25	6.70	4.56	2.45E-05	0.2	−4.6	−2.4
Medial septum	30	3.51	2.98	0.0014	0.4	−0.8	−4.8
Sham > SNL
Insular cortex and piriform cortex	102	7.64	4.89	4.98E-07	−3.2	3.6	−7.0
		4.73	3.69	0.0001	−3.4	3.0	−7.6
		4.60	3.62	0.0001	−3.6	2.6	−5.8
Insular cortex and primary somatosensory cortex	31	4.12	3.35	0.0004	−4.8	3.4	−4.8
Endopiriform nucleus	20	4.06	3.32	0.0005	3.8	1.4	−7.2
Nucleus accumbens	30	3.74	3.12	0.0009	1.6	1.8	−6.4
Piriform cortex	61	3.72	3.11	0.0009	−6.2	−4.8	−8.6
Corpus callosum and caudate putamen	36	3.71	3.11	0.0009	1.6	−0.4	−3.4
Corpus callosum and caudate putamen	76	3.65	3.07	0.0011	3.6	−2.0	−3.8

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