Figure 9 | Scientific Reports

Figure 9

From: Chemotherapy drugs cyclophosphamide, cisplatin and doxorubicin induce germ cell loss in an in vitro model of the prepubertal testis

Figure 9

Proliferation decreases specifically within tubules after exposure to cisplatin or doxorubicin, but not to phosphoramide mustard. (A) Percentage of testis positive for BrdU. This was then examined according to (B) percentage of tubule positive for BrdU; and (C) percentage of interstitium positive for BrdU. (A–C) Quantification was determined after exposure to increasing concentrations of: (i) PM, (ii) CIS or (iii) DOX; n = 8 for all groups. Data are mean + SEM; p < 0.01 (**), p < 0.001 (***) for treatment versus Control.

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