Figure 6
Inhibition of human glioblastoma tumor growth by tail vein–injected tk-VLPs combined with GCV treatment in a subcutaneous xenograft model. Tail vein-injected tk-VLPs, intraperitoneally injected GCV, or combined tk-VLPs/GCV were administered to nude mice bearing subcutaneous U87 human glioblastoma tumors. (a) Gross pictures of tumor nodules harvested on day 21 from each treatment group. Scale bar = 50 mm. (b) Quantification of tumor nodule weights presented as means ± SD. Combined tk-VLPs/GCV treatment exhibited a significant reduction in the weights of tumor nodules compared to tk-VLP only or GCV only treatment. n = 4, Mann-Whitney U Test, *p < 0.05.
