Table 1 Antimicrobial spectrum of compounds 5 and 7. Minimum inhibitory concentration (MIC) was determined against bacteria by broth microdilution assay. Data represent median of three experiments.
Bacteria | MIC (µg/ml) | |
|---|---|---|
5 | 7 | |
Methicillin-susceptible Staphylococcus aureus (MSSA) | ||
  MSSA1 (clinical isolate) | 0.5 | 1 |
  Newman | 0.5 | 1 |
  Smith ATCC13709 | 0.5 | 0.5 |
  RN4220 | 0.5 | 1 |
  NCTC8325 | 0.5 | 1 |
Methicillin-resistant S. aureus (MRSA) | ||
  MRSA4 (clinical isolate) | 0.5 | 1 |
  USA300 FPR3757 (clinical isolate) | 1 | 1 |
Staphylococcus pseudintermedius JCM17571 | 0.125 | 0.5 |
Staphylococcus haemolyticus JCM2416 | 0.25 | 0.25 |
Staphylococcus simulans | 0.25 | 0.5 |
Bacillus subtilis JCM2499 | 1 | 1 |
Bacillus cereus JCM20037 | 1 | 1 |
Streptococcus pneumoniae (clinical isolate) | 1 | 1 |
Streptococcus pyogenes SSI-9 | 8 | 16 |
Streptococcus sanguinis JCM5708 | >128 | >128 |
Streptococcus agalactiae JCM5671 | >128 | >128 |
Enterococcus faecalis EF1 | >128 | >128 |
Vancomycin- resistant E. faecalis EF5 | >128 | >128 |
Listeria monocytogenes 10403S | >128 | >128 |
Escherichia coli W3110 | >128 | >128 |
Pseudomonas aeruginosa PAO1 | >128 | >128 |
