Table 1 Determination of Kd values for de-coppering drugs. The efficiency of de-coppering drugs to demetallate Cu1Cox17 and/or Cu10MT (C50) was in linear correlation with Kd values for Cu(I)-binding complexes (conditions: 20 mM ammonium acetate, pH 7.3, 25 °C).

From: Copper(I)-binding properties of de-coppering drugs for the treatment of Wilson disease. α-Lipoic acid as a potential anti-copper agent

Ligand

C50 (mM) for Cu1Cox17

Kd (M)

DTT

3.10 ± 0.26

5.01 × 10−16*

DETC

0.00528 ± 0.00032

8.53 × 10−19

PA

1.47 ± 0.33

2.38 × 10−16

TR

1.08 ± 0.13

1.74 × 10−16

BAL

0.00938 ± 0.00148

1.52 × 10−18

DMS

0.00314 ± 0.00041

5.07 × 10−19

TTM

 <0.001

 <1.6 × 10−19

DLA

0.498 ± 0.098

8.05 × 10−17

Ligand

C 50 (mM) for Cu 10 MT

K d (M)

DETC

0.772 ± 0.087

8.53 × 10−19

TTM

0.0211 ± 0.0014

2.32 × 10−20

  1. *Taken from reference20.
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