Figure 2

Distinct cell migration patterns can be distinguished by the CN correlation profiles. (a) A CN correlation profile (n = 1500) is constructed using a collection of 25 randomly selected one-hour movies of NIH fibroblasts at one-minute intervals. (b) A CN correlation profile can be separately presented by the histograms of angles (occurrence diagram, top) and the average CCD (<CCD>) over every 5°-polar angle bin, \(\theta \) (CCD diagram, bottom). (c) Two occurrence diagrams and two CCD diagrams, constructed from independent CN correlation profiles of NIH 3T3 fibroblasts (NIH-G1 and NIH-G2), were compared using the Sign test (top) and the Lepage test (bottom). The resulting p-value is displayed by line and bar in the occurrence diagram and the CCD diagram, respectively. The right Y-axis represents the p-value, where the dotted line indicates the p-value = 0.05.