Figure 1
From: The antidepressant fluoxetine acts on energy balance and leptin sensitivity via BDNF
FLX-treated mice show decreased energy balance due to higher energy expenditure. (A) Weight gain with respect to start of FLX treatment for H2O-CFD and FLX-CFD mice. RM 2-way ANOVA (treatment × time, F(3,117) = 8.54, P < 0.0001; n = 18–23) followed by Bonferroni posthoc test, **P < 0.01, ***P < 0.001. (B) Body weight at the end of the treatment. Student’s t-test (t = 3.629 df = 45, ***P = 0.0007; n = 21–26). (C) Food intake during the 3 weeks of treatment for H2O-CFD and FLX-CFD mice (n = 21–26). (D) Daily total energy expenditure of H2O-CFD and FLX-CFD mice measured by doubly labelled water (DLW) method. Student’s t-test (t = 3.046 df = 20, **P = 0.0064; n = 12–10). (E) Infrared locomotor activity monitoring assessed in H2O-CFD and FLX-CFD (number of animals = 6; n = 134). Mann Whitney test (*P = 0.0163). Data are presented as mean ± s.e.m.
