Table 1 IC50 (nM) values toward MMPs.

From: Development of matrix metalloproteinase-targeted probes for lung inflammation detection with positron emission tomography

Compound

MMP-2

MMP-9

MMP-12

MMP-13

ML5

9.6 ± 4.7

37.9 ± 5.2

2.8 ± 0.4

22.4 ± 8.1

I-ML5

3.7 ± 1.0

13.8 ± 1.5

2.3 ± 1.1

11.8 ± 6.3

PFB

77.7 ± 4.0

178.0 ± 24.2

24.2 ± 14.1

66.1 ± 26.1

IPFB

29.1 ± 9.3

148.0 ± 30.6

12.3 ± 4.0

44.5 ± 21.6

PFP

12.5 ± 7.1

54.1 ± 38.3

4.5 ± 2.5

11.1 ± 6.6

IPFP

4.4 ± 2.3

8.1 ± 2.0

1.5 ± 0.8

4.1 ± 1.7

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