Table 3 Subgroup analysis of the association between MGMT hypermethylation and NSCLC or Smoking.

Analysis	Studies N	Patients	OR(95% CI)	Method	Heterogeneity		P value
Analysis	Studies N	Patients	OR(95% CI)	Method	I ² (%)	P value	P value
NSCLC
Ethnicity
Caucasian	12	1239	4.56 [2.63, 7.92]	Fixed	27	0.18	<0.00001
Asian	8	1352	5.18 [2.03, 13.22]	Random	65	0.005	0.0006
Control style
Auologous	17	2305	4.44 [3.32, 5.92]	Random	50	0.01	<0.00001
Heterogeneous	3	286	9.05 [1.79, 45.71]	Fixed	30	0.24	0.008
Detection Method
MSP	17	2167	6.78 [3.40, 13.51]	Random	53	0.006	<0.00001
RT-MSP	3	424	2.91 [1.87, 4.53]	Fixed	0	0.80	<0.00001
Total	20	2591	4.60 [3.46, 6.11]	Fixed	47	0.01	<0.00001
Smoking
Ethnicity
Caucasian	6	700	1.18 [0.48, 2.92]	Random	66	0.01	0.72
Asian	6	706	1.39 [0.61, 3.16]	Random	80	0.0001	0.43
Control style
Auologous	10	1231	0.92 [0.57, 1.49]	Random	52	0.03	0.74
Heterogeneous	2	175	4.92 [2.37, 10.19]	Fixed	0	0.99	<0.0001
Total	12	1406	1.29 [0.73, 2.28]	Random	72	<0.00001	0.39

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