Figure 5
Hypophagic response of the test compounds in twenty four hour fasted rats. Among the tested compounds, 23, 25, 27 and 34 (10 mg/kg, p.o.) showed significant hypophagic activity alone (A) and also suppressed the hyperphagic effect of WIN-55212-2 (2 mg/kg, i.p.) (B) revealing their CB1 receptor antagonist potential. Data expressed as mean ± SEM (n = 6). **p < 0.01, *p < 0.05 vs. vehicle-treated control group (A). #p < 0.01 vs. vehicle-treated control group. ***p < 0.001 vs. WIN-55212-2-treated group (B). One-way ANOVA, Bonferroni post hoc test.
