Table 3 Permeability (Pe) results of the test compounds from the PAMPA-BBB assay with their predicted penetration in CNS. (Data expressed as mean ± SEM of three independent experiments. CNS- indicates low passive CNS permeation).

From: New role of phenothiazine derivatives as peripherally acting CB1 receptor antagonizing anti-obesity agents

Compound

P e (10–6 cm s−1)

Prediction

5

2.78 ± 0.14

CNS-

22

2.28 ± 0.11

CNS-

23

3.08 ± 0.16

CNS-

25

2.72 ± 0.19

CNS-

26

3.66 ± 0.67

CNS-

27

2.80 ± 0.58

CNS-

32

3.22 ± 0.63

CNS-

33

1.05 ± 0.22

CNS-

34

2.09 ± 0.82

CNS-

42

2.60 ± 0.18

CNS-

43

3.47 ± 0.66

CNS-

44

3.58 ± 0.73

CNS-

46

2.84 ± 0.28

CNS-

47

3.28 ± 0.38

CNS-

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