Table 1 Cis-associated gene-SNP pairs with a nominal significant effect on methylphenidate response in the GWAS analysis.

From: Integrative genomic analysis of methylphenidate response in attention-deficit/hyperactivity disorder

Gene	Chr^a	Start base^b	Stop base^c	SNP	SNP base^d	Risk allele	OR (95% CI)	GWAS P-value	Beta	eQTL P-value	eQTL adjusted P-value (FDR)^e
SPSB2	12	6870935	6873357	rs12302749	6867132	T	2.31 (1.22–4.39)	0.011	0.115	3.34e-08	1.13e-05
PYROXD2	10	98383565	98415221	rs1061115	98417292	G	2.23 (1.13–4.41)	0.021	−0.088	1.28e-06	2.17e-04
ARSA	22	50622754	50628173	rs2071421	50625988	T	2.56 (1.06–6.22)	0.037	0.104	8.26e-06	7.26e-04
RRP7A	22	42508335	42519823	rs11553441	42516091	C	3.13 (1.15–8.54)	0.026	0.177	1.04e-05	7.26e-04
CHURC1	14	64914361	64935368	rs4902333	64909368	T	2.37 (1.24–4.51)	8.73e-03	0.116	1.07e-05	7.26e-04
GGH	8	63015079	63039051	rs17279558	63015187	C	3.61 (1.12–11.7)	0.032	0.130	2.38e-04	0.013
SENP3	17	7561992	7571969	rs9901673	7580783	A	3.95 (1.79–8.71)	6.53e-04	0.052	4.66e-04	0.023
PEBP4	8	22713251	22941095	rs17685420	22927888	T	2.87 (1.38–5.94)	4.62e-03	−0.073	9.72e-04	0.041
STRBP	9	123109494	123268576	rs9032	123104493	C	2.28 (1.07–4.85)	0.033	0.071	2.15e-03	0.081
ETFDH	4	158672101	158708713	rs11559290	158680524	C	2.08 (1.01–4.28)	0.048	−0.048	2.57e-03	0.087
CORO7	16	4354542	4416961	rs3810818	4382028	A	2.10 (1.13–3.94)	0.020	−0.053	3.17e-03	0.098
FXR2	17	7591230	7614897	rs9901675	7581494	A	4.12 (1.32–12.9)	0.015	0.130	3.84e-03	0.107
NFIB	9	14081843	14398983	rs7858	14087770	C	2.89 (1.02–8.19)	0.045	−0.055	4.12e-03	0.107
ALDH1L1	3	126103561	126181526	rs2886059	126146923	C	2.73 (1.04–7.14)	0.041	−0.078	5.31e-03	0.129
OPCML	11	132403361	133532983	rs751655	132623600	C	3.08 (1.18–8.02)	0.022	−0.063	7.43e-03	0.158
PURA	5	140114123	140119416	rs2013169	140118020	T	3.32 (1.23–9.01)	0.018	0.071	7.45e-03	0.158
ZDHHC7	16	84974460	85011732	rs3210967	84975857	C	2.09 (1.11–3.94)	0.023	0.056	8.03e-03	0.160
WRB	21	39380287	39397889	rs3761372	39371919	T	3.38 (1.39–8.22)	7.36e-03	0.071	8.54e-03	0.161
FARP2	2	241356249	241494842	rs757978	241431686	C	5.18 (1.19–22.6)	0.029	0.062	0.010	0.181
SENP3	17	7561992	7571969	rs11552708	7559238	A	3.81 (1.50–9.72)	5.05e-03	0.041	0.011	0.189
ZNF565	19	36182060	36215084	rs4805162	36183403	G	2.24 (1.19–4.22)	0.012	0.034	0.016	0.255
ESYT2	7	158730998	158829628	rs1061735	158733764	G	2.91 (1.10–7.67)	0.031	0.030	0.017	0.255
HTT	4	3074510	3243960	rs362272	3233253	G	2.40 (1.06–5.42)	0.035	−0.033	0.019	0.276
CMTM8	3	32238679	32370325	rs4627790	32259860	C	1.98 (1.07–3.68)	0.030	0.054	0.021	0.298
ZNF134	19	57614219	57624717	rs10413455	57620255	A	5.75 (1.35–24.4)	0.018	0.061	0.024	0.323
PDIA2	16	283118	287209	rs1048786	286916	C	3.55 (1.19–10.6)	0.023	−0.087	0.027	0.345
PIGM	1	160027672	160031993	rs12409352	160030645	A	2.67 (1.00–7.12)	0.049	0.029	0.032	0.395
TRIB3	20	380629	397559	rs2295490	388261	G	2.06 (1.06–4.00)	0.033	0.092	0.034	0.406
ZNF211	19	57633167	57644046	rs10420097	57633193	G	7.29 (1.82–29.3)	5.18e-03	0.084	0.038	0.439
ARHGAP12	10	31805398	31928876	rs2799018	31913141	T	1.89 (1.00–3.56)	0.049	−0.036	0.039	0.446
ARHGEF28	5	73626158	73941993	rs929740	73621913	G	2.52 (1.31–4.84)	5.40e-03	−0.037	0.042	0.453
CDH23	10	71396934	71815947	rs17712523	71777857	G	2.61 (1.05–6.48)	0.039	−0.073	0.045	0.475
ELP5	17	7252053	7259940	rs4562	7260420	A	2.22 (1.24–3.95)	6.95e-03	−0.031	0.048	0.497

Note: SNP, single-nucleotide polymorphism; GWAS, genome-wide association study; Chr, gene chromosomal location; OR, odds ratio; CI, confidence interval; eQTL, expression quantitative trait loci.
^a,b,c,dAll relative to the human reference genome GRCh38 (NCBI Build 38).
^eSignificance threshold for the False Discovery Rate (FDR) correction at P < 0.05.

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Table 1 Cis-associated gene-SNP pairs with a nominal significant effect on methylphenidate response in the GWAS analysis.

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