Figure 12

A schematic regulation mechanism of miR-429-CRKL axis on HCC cell malignant behaviours. miR-429 suppresses cell migration and invasion by targeting CRKL via Raf/MEK/ERK-EMT pathway; CRKL promotes tumor cell proliferation through upregulating c-Jun; miR-429 could not inhibit tumor cell proliferation through CRKL/c-Jun pathway.