Figure 2

Quantitative summary of the results of localized MR spectroscopy of HP [1-13C]pyruvate in liver (A) and kidney (B) of Zucker rats, grouped by metabolite. Each metabolite / organ group includes results from three experimental groups as described in text: wild type (WT, Fa/Fa, n = 7), diabetic obese Zucker (fa/fa, n = 6), and diabetic WT-STZ (Fa/Fa-STZ, n = 6) rats. HP metabolite levels are expressed as a fraction of the total 13C signal in the corresponding spectrum. Group means are shown with error bars indicating S.E.M. Statistically significant comparisons from one-way ANOVA are labeled (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001).