Figure 3
From: Human Skeletal Muscle Possesses an Epigenetic Memory of Hypertrophy
(A) Representation of the DNA methylation modifications that occurred within the PI3K/AKT KEGG pathway following 7 weeks of reloading in human subjects. Signalling analysis performed on statistically differentially regulated CpG sites compared to baseline, with green indicating a hypomethylated fold change and red indicating a hypermethylated change, with strength of colour representing the intensity of fold change23,24,25. Figure 3b. Venn diagram analysis of the statistically differentially regulated CpG sites attributed to the PI3K/AKT pathway following loading, unloading and reloading, compared to be baseline. Ellipsis reports number of commonly statistically differentially regulated CpG sites across each condition. Analysis confirms an enhanced number of differentially regulated CpG sites upon reloading condition.
