Figure 6
From: Human Skeletal Muscle Possesses an Epigenetic Memory of Hypertrophy
Representation and characterisation of the DNA methylation modifications that occurred within the ubiquitin mediated proteolysis pathway across all conditions of loading, unloading and reloading compared to baseline (ANOVA). Signalling analysis performed on statistically differentially regulated CpG sites compared to baseline, with green indicating a hypomethylated fold change and red indicating a hypermethylated change, with strength of colour representing the intensity of fold change23,24,25. Importantly, the novel HECT-type E3 ubiquitin ligase, UBR5, displays a significantly hypomethylated state within this pathway.
