Figure 3
From: Polygonum aviculare L. extract and quercetin attenuate contraction in airway smooth muscle
Nifedipine blocks LVDCC-mediated contraction and current. (a) A high concentration of K+ (80 mM) induced a contraction in a mouse TR, which was almost blocked by the LVDCC inhibitor nifedipine. (b) The protocol used to record the LVDCC-mediated current in single mouse tracheal ASM cells (top). The current was completely blocked by nifedipine (middle). Current-voltage curves (bottom). These results indicate that high K+-induced contraction might be completely mediated by LVDCCs.
