Figure 6
From: Polygonum aviculare L. extract and quercetin attenuate contraction in airway smooth muscle
EAF attenuates ACH-induced current and TR contraction. (a) ACH-induced currents, similarly recorded as shown in Fig. 4E, were completely blocked by EAF. (b) Under Ca2+-free conditions (0 Ca2+ + 0.5 mM EGTA), ACH induced transient contractions in a TR incubated in nifedipine. After the addition of 2 mM Ca2+, a large sustained contraction was observed in the TR, which was attenuated by EAF. These results indicate that TRPC3 and/or STIM/Orai channels are likely blocked by EAF and contribute to EAF-induced relaxation.
